PROMs: PEG 7.3 · PHQ-9 15 · GAD-7 11 · ISI 18 · WHODAS 32
history: prior gabapentin escalation → DC for sedation @ 1800mg. SSRI naïve. No opioid exposure.
phenotype: central-sensitization-mediated, with affective + sleep components
safety: CYP2D6 normal (chart-confirmed) · QTc 412ms · no serotonergic burden
Recommended plan
P01P02Initiate nortriptyline 10mg qHS · titrate to 25–50mg over 4 weeks
Addresses descending NE tone and sleep architecture in a single agent. Combination therapy outperforms either monotherapy at maximum tolerated dose. Single-agent consolidation per Pattern 01; integrated pain-BH circuit logic per Pattern 02.
Source · Gilron et al., Lancet 2009 — RCT, n=56, DPN/PHN
P01Hold further gabapentin escalation
Sedation-limited at 1800mg in this patient. Phenotype favors NE/sleep mechanism over additional Ca²⁺-α2δ binding. Avoid medication stacking absent mechanistic rationale.
Source · prior chart, encounter 2025-11-08
P02Refer to CBT-CP · 6-session protocol
Behavioral component for sensitization-mediated phenotype with affective overlap. Concurrent with pharmacologic titration. Pain + BH treated as one circuit problem, not two parallel tracks.
Source · ACCESS Track 1 behavioral integration guidance
Monitoring · companion-driven
cadence: weekly PEG, PHQ-9, ISI · daily flare/sleep · adherence + side-effect prompts
stepped-care trigger: P04Week-4 PEG reduction <30% → re-evaluate; consider duloxetine cross-titration or low-dose naltrexone augmentation
forecast: attainment-probability output suppressed pending model calibration on Polaris cohort (n<50)
Documentation · pre-bill check
G3002: all elements present · 24 min QHP time recorded · care plan updated · PROMs documented
audit packet: ready · P05 11 source artifacts linked · attestation pending